Kinetic Modelling In Systems Biology

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Author: Oleg Demin
Publisher: CRC Press
ISBN: 9781420011661
Size: 75.79 MB
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Kinetic Modelling In Systems Biology by Oleg Demin


Original Title: Kinetic Modelling In Systems Biology

With more and more interest in how components of biological systems interact, it is important to understand the various aspects of systems biology. Kinetic Modelling in Systems Biology focuses on one of the main pillars in the future development of systems biology. It explores both the methods and applications of kinetic modeling in this emerging field. The book introduces the basic biological cellular network concepts in the context of cellular functioning, explains the main aspects of the Edinburgh Pathway Editor (EPE) software package, and discusses the process of constructing and verifying kinetic models. It presents the features, user interface, and examples of DBSolve as well as the principles of modeling individual enzymes and transporters. The authors describe how to construct kinetic models of intracellular systems on the basis of models of individual enzymes. They also illustrate how to apply the principles of kinetic modeling to collect all available information on the energy metabolism of whole organelles, construct a kinetic model, and predict the response of the organelle to changes in external conditions. The final chapter focuses on applications of kinetic modeling in biotechnology and biomedicine. Encouraging readers to think about future challenges, this book will help them understand the kinetic modeling approach and how to apply it to solve real-life problems. CD-ROM Features Extensively used throughout the text for pathway visualization and illustration, the EPE software is available on the accompanying CD-ROM. The CD also includes pathway diagrams in several graphical formats, DBSolve installation with examples, and all models from the book with dynamic visualization of simulation results, allowing readers to perform in silico simulations and use the models as templates for further applications.

The Biology Of Alcoholism

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Author: Benjamin Kissin
Publisher: Springer Science & Business Media
ISBN: 146840895X
Size: 22.86 MB
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The Biology Of Alcoholism by Benjamin Kissin


Original Title: The Biology Of Alcoholism

Alcoholism is a uniquely human condition. Although some forms of alcohol dependence can be induced experimentally in a variety of laboratory animals, the complete spectrum of alcoholism with all of its physical, psychological, and social implications occurs only in man. The special quality of this relationship becomes more significant when one considers that the manifestations of most physical disease syndromes in animals and man are more similar than they are different. The uniqueness of alcoholism lies in the fact that it is one of the few physical diseases which reflects at all levels the problems of individuals coping with the complexities of human society. In order to present a more coherent picture of these complex relationships, we have attempted to impose a logical sequence upon the material. This sequence lies along a dual parameter-from the physical to the social and from the theor etical to the empirical. Consequently, it was natural for the first volume in this series to deal with biochemistry, the most basic and physical aspect of the inter action of alcohol and man. It is equally natural for this, the second volume, to deal with physiology and behavior, for these levels of phenomenology-partic ularly the latter-are already more empirical and psychological in their mani festations. Finally, the third volume, clinical pathology, describes the disease itself, with all of the medical and social implications carried in the word "alcoholism.

Statistical Tools In Human Biology Proceedings Of The 17th Course Of The International School Of Mathematics G Stampacchia

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Author: Di Bacco M
Publisher: World Scientific
ISBN: 9814550833
Size: 39.71 MB
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Statistical Tools In Human Biology Proceedings Of The 17th Course Of The International School Of Mathematics G Stampacchia by Di Bacco M


Original Title: Statistical Tools In Human Biology Proceedings Of The 17th Course Of The International School Of Mathematics G Stampacchia

Inequalities play an important role in almost all branches of mathematics as well as in other areas of science and engineering. This book surveys the present state of the theory of weighted integral inequalities of Hardy type, including modifications concerning Hardy-Steklov operators, and some basic results about Hardy type inequalities and their limit (Carleman-Knopp type) inequalities. It also describes some rather new fields such as higher order and fractional order Hardy type inequalities and integral inequalities on the cone of monotone functions together with some applications and open problems. The book can serve as a reference and a source of inspiration for researchers working in these and related areas, but could also be used for advanced graduate courses.

Philosophy Of Biology

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Author: Brian Garvey
Publisher: Routledge
ISBN: 1317493672
Size: 13.11 MB
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Philosophy Of Biology by Brian Garvey


Original Title: Philosophy Of Biology

This major new series in the philosophy of science aims to provide a new generation of textbooks for the subject. The series will not only offer fresh treatments of core topics in the theory and methodology of scientific knowledge, but also introductions to newer areas of the discipline. Furthermore, the series will cover topics in current science that raise significant foundational issues both for scientific theory and for philosophy more generally. Biology raises distinct questions of its own not only for philosophy of science, but for metaphysics, epistemology and ethics. This comprehensive new textbook for a rapidly growing field of study provides students new to the subject with an up-to-date presentation of the key philosophical issues. Care is taken throughout to keep the technicalities accessible to the non-biologist but without sacrificing the philosophical subtleties. The first part of the book covers the philosophical challenges posed by evolution and evolutionary biology, beginning with Darwin's central argument in the Origin of the Species. Individual chapters cover natural selection, the selfish gene, alternative units of selection, developmental systems theory, adaptionism and issues in macroevolution. The second part of the book examines philosophical questions arising in connection with biological traits, function, nature and nurture, and biological kinds. The third part of the book examines metaphysical questions, biology's relation with the traditional concerns of philosophy of science, and how evolution has been introduced into epistemological debates. The final part considers the relevance of biology to questions about ethics, religion and human nature.

Human Biology

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Author: Sara Stinson
Publisher: John Wiley & Sons
ISBN: 1118108043
Size: 15.87 MB
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Human Biology by Sara Stinson


Original Title: Human Biology

This comprehensive introduction to the field of human biology covers all the major areas of the field: genetic variation, variation related to climate, infectious and non-infectious diseases, aging, growth, nutrition, and demography. Written by four expert authors working in close collaboration, this second edition has been thoroughly updated to provide undergraduate and graduate students with two new chapters: one on race and culture and their ties to human biology, and the other a concluding summary chapter highlighting the integration and intersection of the topics covered in the book.

Humans In Nature

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Author: Gregory E. Kaebnick
Publisher: Oxford University Press
ISBN: 0199347239
Size: 28.72 MB
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Humans In Nature by Gregory E. Kaebnick


Original Title: Humans In Nature

Contemporary debates over issues as wide-ranging as the protection of wildernesses and endangered species, the spread of genetically modified organisms, the emergence of synthetic biology, and the advance of human enhancement, all of which seem to spin into deeper and more baffling questions with every change in the news cycle, often circle back to the same fundamental question: should there be limits to the human alteration of the natural world? A growing number of people view the human capacity to alter natural states of affairs -- from formerly wild spaces and things around us to crops and livestock to our own human nature -- as cause for moral alarm. That reaction raises a number of perplexing philosophical questions, however: Can we identify "natural" states of affairs at all? Does the idea of being morally concerned about the human relationship to nature make any sense? Should such a concern influence public policy and politics, or should government stay strenuously neutral on such matters? Through a study of moral debates about the environment, agricultural biotechnology, synthetic biology, and human enhancement, Gregory E. Kaebnick, a research scholar at The Hastings Center and editor of the Hastings Center Report, argues that concerns about the human alteration of nature can be legitimate and serious, but also that they are complex, contestable, and of limited political force. Kaebnick defends attempts to identify "natural" states of affairs by disentangling the nature/artifact distinction from metaphysical hoariness. Drawing on David Hume, he also defends moral standards for the human relationship to nature, arguing that they, and moral standards generally, should be understood as grounded in what Hume called the "passions." Yet what counts as "natural" can be delineated only roughly, he concludes, and moral standards for interaction with nature are less a matter of obligation than of ideals. Kaebnick also concludes, drawing on an interpretation of the liberal principle of neutrality, that government may support those standards but must be careful not to enforce them. Thus Kaebnick looks for a middle way on debates that have tended toward polarization. "As differences between nature and artifact become steadily less substantial, problems about preservation run to the core of how people can make sense of themselves, of each other, and of our shared world. Kaebnick's solutions are creative and compelling, theoretically elegant and politically practical. Providing distinctive ways forward, when much academic and policy discussion seems exhausted, his book demands wide attention. In return, it inspires hope." - James Nelson, Michigan State University

Classification Evolution And The Nature Of Biology

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Author: Alec L. Panchen
Publisher: Cambridge University Press
ISBN: 9780521315784
Size: 79.55 MB
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Classification Evolution And The Nature Of Biology by Alec L. Panchen


Original Title: Classification Evolution And The Nature Of Biology

Historically, naturalists who proposed theories of evolution, including Darwin and Wallace, did so in order to explain the apparent relationship of natural classification. This book begins by exploring the intimate historical relationship between patterns of classification and patterns of phylogeny. However, it is a circular argument to use the data for classification. Alec Panchen presents other evidence for evolution in the form of a historically based but rigorously logical argument. This is followed by a history of methods of classification and phylogeny reconstruction including current mathematical and molecular techniques. The author makes the important claim that if the hierarchical pattern of classification is a real phenomenon, then biology is unique as a science in making taxonomic statements. This conclusion is reached by way of historical reviews of theories of evolutionary mechanism and the philosophy of science as applied to biology. The book is addressed to biologists, particularly taxonomists, concerned with the history and philosophy of their subject, and to philosophers of science concerned with biology. It is also an important source book on methods of classification and the logic of evolutionary theory for students, professional biologists, and paleontologists.

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